The Vitamin D Receptor

The vitamin D receptor (VDR) is a protein that is turned on by calciferol. It is associated with maintaining the mineral harmony in the body and causing growth and hair development. It also treats adipose structure.

VDRs will be expressed inside the parathyroid glands, intestines, epithelial cellular material, and many immune system cell types. They are thought to regulate the intestinal consumption of calcium, and to mediate some of the effects of vitamin D upon bone protection. They are also thought to play an important purpose in metabolic process.

VDR can be found in a variety of areas, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they can be most widely stated in the kidneys and bone.

The VDR is comparison of data room software phosphorylated about serine elements by several protein kinases. These kinases include PKA and PKC. The effect these kinases in VDR is definitely ligand centered. Specifically, the phosphorylation of Ser51 by PKC lowered VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.

Studies have shown that VDRs can be found in a part of glial cells, specifically in oligodendrocytes in white matter. Although VDR immunoreactivity has been diagnosed in a number of glial cell lines, no proof has been shown that the occurrence of VDR in glia is a cause for increased likelihood of tumorigenesis.

Additionally , VDR looks present in a subset of neurons. Actually nuclear discoloration has been has confirmed in our cortex and glial cell-lines.

A large 220-kDa protein can be found in human key glioblastoma cellular material. In contrast, a little recombinant VDR-like protein was produced.

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